tert-butyl 3-cyanobenzoate synthesis
- Product Name:tert-butyl 3-cyanobenzoate
- CAS Number:383185-76-0
- Molecular formula:C12H13NO2
- Molecular Weight:203.24
1711-11-1
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Yield: 82.1%
Reaction Conditions:
with pyridine;dmap in dichloromethane at 0 - 20; for 20 h;
Steps:
1.A.B
To a mixture of tert-butanol (3.50 g, 47.22 mmol), pyridine (3.72 g, 46.78 mmol) and cat. DMAP in methylene chloride (15 mL) is added dropwise 3-cyanobenzoyl chloride (6.81 g, 41.07 mmol) and pyridine (3 mL) in methylene chloride (10 mL) at 0 °C. The resulting mixture is stirred at room temperature for 20 h. The solvent is evaporated, and the residue is purified by flash chromatography (1:1 methylene EPO
References:
PTC THERAPEUTICS, INC. WO2006/44505, 2006, A2 Location in patent:Page/Page column 82-83
