ChemicalBook CAS DataBase List TERT-BUTYL 3 HYDROXY-4-NITROBENZOATE

TERT-BUTYL 3 HYDROXY-4-NITROBENZOATE synthesis

5synthesis methods

Product Name:TERT-BUTYL 3 HYDROXY-4-NITROBENZOATE
CAS Number:123330-86-9
Molecular formula:C11H13NO5
Molecular Weight:239.22

157665-52-6
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123330-86-9
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Yield:123330-86-9 99%

Reaction Conditions:

with 2-(methylsulfonyl)ethyl alcohol;sodium hydride in N,N-dimethyl-formamide at 0; for 3 h;

Steps:

A3 Synthesis of Compound 4 A.

2-(Methylsulfonyl-ethanol) (154 mg, 1.24 mmol) was added to a stirring solution of Compound 2E (200 mg, 829.14 pmol) in DMF (1.26 mL), and the resulting mixture was cooled to 0 °C. NaH (59 mg, 2.49 mmol) was then added, and the reaction was stirred for 3 hours. The reaction was then warmed to room temperature, quenched with a IN HC1 solution, and partitioned between ethyl acetate and brine. The organic layer was concentrated to dryness, and the residue was purified flash column chromatography to afford Compound 4A (198.5 mg, 827.6 pmol, 99% yield).

References:

WO2021/178907,2021,A1 Location in patent:Paragraph 0275

619-14-7 Synthesis