tert-butyl (4-bromothiazol-2-yl)methylcarbamate synthesis
- Product Name:tert-butyl (4-bromothiazol-2-yl)methylcarbamate
- CAS Number:697299-87-9
- Molecular formula:C9H13BrN2O2S
- Molecular Weight:293.18
697299-86-8
33 suppliers
$45.00/10mg
24424-99-5
821 suppliers
$13.50/25G
697299-87-9
62 suppliers
$136.00/100mg
Yield:697299-87-9 72%
Reaction Conditions:
in 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at 20; for 4 h;
Steps:
5.D N-cyano-N'-(4-{4-[3-Methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-thiazol-2-ylmethyl)guanidine
Step D: (4-Bromo-thiazol-2-ylmethyl)-carbamic acid tert-butyl ester (4-Bromo-thiazol-2-yl)-methylamine (705.3 mg, 3.68 mmol) is dissolved in anhydrous DCM (15 ml) and Boc2O (898 mg, 4.13 mmol) is added. The reaction mixture is stirred at room temperature for 4 hours. Flash chromatography on silica with 0-20% EtOAc-hexanes affords 770 mg (2.64 mmol, 72%) of pure desired product.
References:
US2005/101617,2005,A1 Location in patent:Page/Page column 10
4248-19-5
374 suppliers
$5.00/5g
697299-87-9
62 suppliers
$136.00/100mg