tert-Butyl (4-(chloroMethyl)pyridin-2-yl)carbaMate synthesis
- Product Name:tert-Butyl (4-(chloroMethyl)pyridin-2-yl)carbaMate
- CAS Number:672324-82-2
- Molecular formula:C11H15ClN2O2
- Molecular Weight:242.702
304873-62-9
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Yield:672324-82-2 94%
Reaction Conditions:
with thionyl chloride in dichloromethane at 25; for 2 h;
Steps:
222.B PREPARATIVE EXAMPLE 222; STEP B
The crude alcohol from Preparative Example 222, step A (0.4 g, 1.78 MMOL) in CH2CI2 (4 mL) was added SOCI2 (0.65 mL, 8.91 MMOL) and the mixture was stirred for 2 h at rt. The mixture was concentrated under reduced pressure to afford 407 mg (94%) of a light yellow solid. M+H = 243. The crude product was taken on without further purification
References:
WO2004/22561,2004,A1 Location in patent:Page 96