ChemicalBook CAS DataBase List TERT-BUTYL 4-CYANOPHENYLCARBAMATE

TERT-BUTYL 4-CYANOPHENYLCARBAMATE synthesis

11synthesis methods

Product Name:TERT-BUTYL 4-CYANOPHENYLCARBAMATE
CAS Number:143090-18-0
Molecular formula:C12H14N2O2
Molecular Weight:218.25

24424-99-5 Synthesis

24424-99-5
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$13.50/25G

873-74-5
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$9.00/1g

143090-18-0
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$22.50/1g

Yield: 88%

Reaction Conditions:

with sulfonated reduced graphene oxide in neat (no solvent) at 20; for 3 h;

Steps:

Boc Protection of Amines; General Procedure
General procedure: To a magnetically stirred solution of (Boc)2 (1 mmol, 218.25 mg) andSrGO (7.5 mg), was added the respective amine (1 mmol) and stirredfor the appropriate time (Table 2) at RT. The progress of the reactionwas monitored by TLC. After the completion of the reaction, DCM (2mL) was added to the reaction mixture and the catalyst was separatedby vacuum filtration. The catalyst was washed with EtOH (3 × 5 mL)and subsequently dried in an air oven at 70 °C for 3 h and reused forfurther reactions. The solvent was concentrated under reduced pressureto yield N-t-Boc protected amine derivatives. The products werecharacterized by 1H NMR, 13C NMR, MS, and IR spectroscopy.

References:

Awasthi, Satish K.;Mishra, Anupam;Mittal, Rupali [Synthesis,2020,vol. 52,# 4,p. 591 - 601]

4248-19-5 Synthesis