tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate synthesis
- Product Name:tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate
- CAS Number:821767-61-7
- Molecular formula:C9H12N2O3
- Molecular Weight:196.2
24424-99-5
821 suppliers
$13.50/25G
35344-95-7
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$32.00/1g
821767-61-7
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$65.00/100mg
Yield:821767-61-7 98 %
Reaction Conditions:
in acetonitrile at 25;
Steps:
IV.6 Synthesis of tert-butyl 4-formyl-1H-pyrazole-1-carboxylate.
Di-tert-butyl dicarbonate (4.54 g, 20.81 mmol) was added to a solution of 1H-pyrazole-4-carbaldehyde (2.0 g, 20.81 mmol) in MeCN (21 ml) and the mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo to give an oil, which was diluted with water (20 mL) and extracted with EtOAc (3 x 20 mL). The organic phases were combined, washed with HC1 (0.5M aq., 20 mL), brine (20 mL), passed through a phase separator cartridge and concentrated in vacuo to give the title compound (4.04 g, 98 %) as a pale yellow solid. 1 H NMR (400 MHz, DMSO) δ 9.93 (s, 1H), 9.04 (s, 1H), 8.22 (s, 1H), 1.61 (s, 9H).
References:
WO2022/197763,2022,A1 Location in patent:Paragraph 0356
199003-22-0
55 suppliers
$45.00/50mg
821767-61-7
69 suppliers
$65.00/100mg
24424-99-5
821 suppliers
$13.50/25G
821767-61-7
69 suppliers
$65.00/100mg