ChemicalBook CAS DataBase List tert-butyl 4-hydroxy-2-nitrophenylcarbaMate

tert-butyl 4-hydroxy-2-nitrophenylcarbaMate synthesis

4synthesis methods

Product Name:tert-butyl 4-hydroxy-2-nitrophenylcarbaMate
CAS Number:201811-20-3
Molecular formula:C11H14N2O5
Molecular Weight:254.24

24424-99-5 Synthesis

24424-99-5
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$13.50/25G

610-81-1 Synthesis

610-81-1
334 suppliers
$5.00/5g

tert-butyl 4-hydroxy-2-nitrophenylcarbaMate

201811-20-3
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Yield: 95%

Reaction Conditions:

with dmap;triethylamine in dichloromethane at 25; for 2 h;

Steps:

8.1 Step 1 to synthesize compound 12
4-amino-3-nitro-phenol (1.5 g, 9.73 mmol), B0C2O (3.19 g, 14.60 mmol) and Et3N (984 mg, 9.73 mmol) dissolved in DCM (10 mL). Then a solution of DMAP (118 mg, 0.973 mmol) in DCM (10 mL) was slowly added dropwise to the above solution. Then the mixture was stirred at 25°C for 2 hours. The mixture was concentrated under reduced pressure to remove DCM. The residue was purified by silica gel chromatography. (ISCO; 20 g SepaFlash Silica Flash Column, Eluent of 0-30% Ethyl acetate/Petr oleum ether gradient 40 mL/min) to afford tert-butyl A-(4-hydroxy-2-nitro-phenyl (carbamate (2.35 g, 95% yield) as a yellow solid. LCMS: /_R = 1.169 min in 10- 80AB_2min_220&254_Shimadzu.lcm, MS (ESI) m/z = 255.1 [M+H]⁺.

References:

BRIDGENE BIOSCIENCES, INC.;CAO, Ping;ZHANG, Chao;BISHOP, Michael, J. WO2020/168237, 2020, A1 Location in patent:Paragraph 00173; 00174

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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201811-20-3
26 suppliers
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References

610-81-1 Synthesis

610-81-1
334 suppliers
$5.00/5g

201811-20-3
26 suppliers
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References

4-(tert-Butyldimethylsilyl)oxy-2-nitroaniline

215656-99-8
10 suppliers
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201811-20-3
26 suppliers
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References