ChemicalBook CAS DataBase List tert-butyl 5,6-dichloropyridin-3-ylcarbamate

tert-butyl 5,6-dichloropyridin-3-ylcarbamate synthesis

2synthesis methods

Product Name:tert-butyl 5,6-dichloropyridin-3-ylcarbamate
CAS Number:275383-96-5
Molecular formula:C10H12Cl2N2O2
Molecular Weight:263.12

41667-95-2 Synthesis

41667-95-2
387 suppliers
$6.00/1g

75-65-0 Synthesis

75-65-0
760 suppliers
$10.00/10ml

tert-butyl 5,6-dichloropyridin-3-ylcarbamate

275383-96-5
31 suppliers
$355.00/1g

Yield:275383-96-5 58%

Reaction Conditions:

with diphenyl phosphoryl azide;triethylamine at 80; for 18 h;

Steps:

12.A

A mixture of 5,6-dichloronicotinic acid (5.0 g, 26.0 mmol), diphenylphosphoryl azide (7.1 g, 26. 0 mmol), and triethylamine (2.63 g, 26.0 mmol) in t-butanol (50 mL) was heated at EPO 80 ⁰C for 18 h. The reaction mixture was cooled to room temperature and poured into ice water. The product was extracted with ethyl acetate. The extracts were washed with water, 10% sodium carbonate and brine and evaporated to give a brown oil which was purified on a silica gel column using hexane/ethyl acetate (1:1) to obtain the product (3.9g, 58 %) as a white solid.

References:

WO2006/112828,2006,A1 Location in patent:Page/Page column 85-86

24424-99-5 Synthesis

24424-99-5
842 suppliers
$13.50/25G

98121-41-6 Synthesis

98121-41-6
195 suppliers
$8.00/250mg

275383-96-5
31 suppliers
$355.00/1g

References