![](/CAS/GIF/853070-30-1.gif)
TERT-BUTYL 5-AMINO-2-FLUOROBENZOATE synthesis
- Product Name:TERT-BUTYL 5-AMINO-2-FLUOROBENZOATE
- CAS Number:853070-30-1
- Molecular formula:C11H14FNO2
- Molecular Weight:211.2328
![2-FLUORO-5-NITRO-BENZOIC ACID TERT-BUTYL ESTER](/CAS/GIF/526218-22-4.gif)
526218-22-4
19 suppliers
$119.00/100mg
![TERT-BUTYL 5-AMINO-2-FLUOROBENZOATE](/CAS/GIF/853070-30-1.gif)
853070-30-1
19 suppliers
$130.00/50mg
Yield:-
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in tetrahydrofuran; for 6 h;
Steps:
181
Reference Example 181 tert-Butyl 5-amino-2-fluorobenzoate [Show Image] To a solution of tert-butyl 2-fluoro-5-nitrobenzoate (500 mg) in tetrahydrofuran (50 mL) was added 10% palladium-active carbon carrier (containing 50% water, 58 mg), and the resulting mixture was stirred for 6 hours under a hydrogen atmosphere. The reaction solution was filtered and the filtrate was concentrated under reduced pressure to obtain the title compound (447.2 mg) as a yellow oil. 1H NMR (400 MHz, CDCl3) δ 7.14-7.11 (m, 1H), 6.92-6.88 (m, 1H), 6.78-6.74 (m, 1H), 3.62 (brs, 2H), 1.53 (s, 9H). MS (ESI+) 212 (M+ + 1, 67%), 156 (100%).
References:
EP1690863,2006,A1 Location in patent:Page/Page column 177