![](/CAS/GIF/73839-20-0.gif)
tert-Butyl 6-Hydroxyhexanoate synthesis
- Product Name:tert-Butyl 6-Hydroxyhexanoate
- CAS Number:73839-20-0
- Molecular formula:C10H20O3
- Molecular Weight:188.26
![ε-Caprolactone](/CAS/GIF/502-44-3.gif)
502-44-3
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$5.00/25g
![tert-Butanol](/CAS/GIF/75-65-0.gif)
75-65-0
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$10.00/10ml
![tert-Butyl 6-Hydroxyhexanoate](/CAS/GIF/73839-20-0.gif)
73839-20-0
55 suppliers
$140.00/1g
Yield: 80%
Reaction Conditions:
with potassium tert-butylate in dichloromethane for 3 h;Reflux;Inert atmosphere;
Steps:
3.1 Preparation of 6-Hydroxy-hexanoic acid tert-butyl ester (15)
To a 250 mL round bottom flask equipped with a magnetic stirrer, thermocouple, condenser and nitrogen inlet was charged 6-hexanolactone 14 (3.7 g; 32 mmol) and i-BuOH (100 mL) in DCM followed by i-BuOK (3.9 g; 35 mmol; 1.1 equiv.). This solution was stirred and heated to reflux for 3 hours. The solution was diluted with toluene, washed with water and brine, dried over Na2S04, filtered and concentrated to afford 4.8 g (80% yield) as a clear yellow oil. 1H-NMR (500 MHz, CDC13): δ 3.65 - 3.62 (m, 2H), 2.32 - 2.29 (m, 1H), 2.23 - 2.20 (m, 2H), 1.66 - 1.55 (m, 4H), 1.43 (s, 9H), 1.41 - 1.35 (m, 2H).
References:
REGENERON PHARMACEUTICALS, INC.;NITTOLI, Thomas;KUNZ, Arthur WO2015/187596, 2015, A2 Location in patent:Paragraph 00244
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1000075-04-6
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![tert-Butyl 6-Hydroxyhexanoate](/CAS/GIF/73839-20-0.gif)
73839-20-0
55 suppliers
$140.00/1g
![Hexanoic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/874796-67-5.gif)
874796-67-5
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![tert-Butyl 6-Hydroxyhexanoate](/CAS/GIF/73839-20-0.gif)
73839-20-0
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$140.00/1g
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65868-63-5
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$44.00/100mg
![tert-Butyl 6-Hydroxyhexanoate](/CAS/GIF/73839-20-0.gif)
73839-20-0
55 suppliers
$140.00/1g
![ε-Caprolactone](/CAS/GIF/502-44-3.gif)
502-44-3
339 suppliers
$5.00/25g
![Potassium tert-butoxide](/CAS/GIF/865-47-4.gif)
865-47-4
664 suppliers
$14.00/25g
![tert-Butanol](/CAS/GIF/75-65-0.gif)
75-65-0
741 suppliers
$10.00/10ml
![tert-Butyl 6-Hydroxyhexanoate](/CAS/GIF/73839-20-0.gif)
73839-20-0
55 suppliers
$140.00/1g