tert-butyl (pyrazin-2-yl)methylcarbamate synthesis
- Product Name:tert-butyl (pyrazin-2-yl)methylcarbamate
- CAS Number:1026790-47-5
- Molecular formula:C10H15N3O2
- Molecular Weight:209.24
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Yield:1026790-47-5 100%
Reaction Conditions:
in isopropyl alcohol at 20; for 2 h;
Steps:
20 Synthesis of pyrazin-2-ylmethyl-carbamic acid tert-butyl ester (Compound AA)
To a solution of 2-aminomethyl-pyrazine (5.0 g, 45.87 mmol) in isopropanol (50 ml) was added di-tert-butyl-pyrocarbonate (12.0 g, 55.84 mmol); the mixture was stirred at ambient temperature for 2 h. Next, the solvent was evaporatedand the residue was dissolved in DCM (30 ml), and subjected to silica gel purification (chloroformlmethanol gradient 0-30% in 100 mm.). Fractions containing desired product were combined and evaporated. Residue was dried under vacuum to provide Compound AA in quantitative yield(10.22 g, 99% purity) as amorphous solid. LC-MS: (mlz) observed (M+H) 210.5 (C10H15N302+H calc: 210.3)
References:
US9139612,2015,B2 Location in patent:Page/Page column 151