ChemicalBook CAS DataBase List tert-Butyl thiomorpholine-4-carboxylate

tert-Butyl thiomorpholine-4-carboxylate synthesis

4synthesis methods

Product Name:tert-Butyl thiomorpholine-4-carboxylate
CAS Number:215791-95-0
Molecular formula:C9H17NO4S
Molecular Weight:235.3

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Yield: 88%

Reaction Conditions:

with dihydrogen peroxide in acetic acid at 0 - 50; for 4 h;

Steps:

2 5.1.6.2 Tert-butyl thiomorpholine-4-carboxylate 1,1-dioxide (11)
To the solution of 10 (5g, 0.024mol) in 83 AcOH (15mL), 19 H₂O₂ (40%, 5mL) was added dropwise while maintaining the temperature below 0°C. After the addition was completed, the mixture was heated to 50°C for another 4h. After completion of the reaction as indicated by TLC, the reaction was quenched by adding saturated 84 sodium thiosulfate solution (15mL), Then 22 DCM (30mL) was added and the misture was washed with water and brine, dried over MgSO₄, filtered, and concentrated under reduced pressure to yield 40 1 as a light yellow solid in 88% yield.

References:

Wu, Yachuang;Ding, Xiudong;Ding, Liang;Zhang, Yongsheng;Cui, Lei;Sun, Lu;Li, Wei;Wang, Di;Zhao, Yanfang [European Journal of Medicinal Chemistry,2018,vol. 158,p. 247 - 258]

39093-93-1 Synthesis