ChemicalBook CAS DataBase List tetrahydro-5-hydroxy-1H-pyrimidin-2-one

tetrahydro-5-hydroxy-1H-pyrimidin-2-one synthesis

5synthesis methods

Product Name:tetrahydro-5-hydroxy-1H-pyrimidin-2-one
CAS Number:1852-18-2
Molecular formula:C4H8N2O2
Molecular Weight:116.12

5807-14-7
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$6.00/1g

616-29-5
315 suppliers
$15.00/10g

105-58-8
450 suppliers
$17.00/25g

1852-18-2
31 suppliers
$45.00/5mg

Yield:1852-18-2 100%

Steps:

Synthesis of 5-hydroxytetrahydropyrimidin-2-one (11)

Monomer Synthesis Example 1-1 Synthesis of 5-hydroxytetrahydropyrimidin-2-one (11) A mixture of 49.1 g of 1,3-diamino-2-propanol (10), 64.4 g of diethyl carbonate, and 3.79 g of 1,5,7-triazabicyclo[4.4.0]dec-5-ene was stirred and heated under reflux for 6 hours. Stirring was continued for a further 10 hours while gradually removing ethanol formed during reaction. Thereafter, the solvent and diethyl carbonate were distilled off in vacuum, obtaining 64.4 g of the end compound, 5-hydroxytetrahydropyrimidin-2-one (11). Yield 100%. The end compound was used in the subsequent step without further purification. ¹H-NMR (600 MHz in CDCl₃): δ = 2.91 (2H, dd), 3.13 (2H, dd), 3.81 (1H, tt), 5.96 (2H, s) ppm

References:

EP2412733,2012,A1

616-29-5
315 suppliers
$15.00/10g

105-58-8
450 suppliers
$17.00/25g

1852-18-2
31 suppliers
$45.00/5mg

References

868-84-8 Synthesis