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Thailanstatin C synthesis
- Product Name:Thailanstatin C
- CAS Number:1426953-24-3
- Molecular formula:C30H46ClNO9
- Molecular Weight:600.14
![Carbamic acid, N-[(2R,3R,5S,6S)-tetrahydro-2,5-dimethyl-6-(2-propen-1-yl)-2H-pyran-3-yl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/882028-43-5.gif)
882028-43-5
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![Thailanstatin C](/CAS/20210305/GIF/1426953-24-3.gif)
1426953-24-3
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Yield:-
Steps:
Multi-step reaction with 8 steps
1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere
2: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 25 °C / Inert atmosphere
3: potassium carbonate / methanol / 1 h / 25 °C
4: dmap / dichloromethane / 3 h / 25 °C
5: 1,3-bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene)dichloro(5-nitro-2-isopropoxyphenylmethylene)ruthenium / dichloromethane / 5 h / 50 °C / Inert atmosphere
6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; thallium(I) carbonate / water; tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
7: lithium chloride; acetic acid / 1 h / 25 °C
8: formic acid / 4 h / 25 °C / Inert atmosphere
References:
Nicolaou;Rhoades, Derek;Kumar, S. Mothish [Journal of the American Chemical Society,2018,vol. 140,# 26,p. 8303 - 8320]
![2-Pentenoic acid, 4-(acetyloxy)-, (2Z,4S)-](/CAS/20210305/GIF/310397-89-8.gif)
310397-89-8
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![Thailanstatin C](/CAS/20210305/GIF/1426953-24-3.gif)
1426953-24-3
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