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1826-18-2

Thiazole, 5-methyl-4-phenyl- synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: ethanol / Reflux
2: sodium hydroxide; water / ethanol / 20 °C
3: hydrogenchloride / 1,4-dioxane; water / Reflux

References:

Nitta, Aiko;Fujii, Hideaki;Sakami, Satoshi;Satoh, Mikiya;Nakaki, Junko;Satoh, Shiho;Kumagai, Hiroki;Kawai, Hideki [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 23,p. 7036 - 7040]