ChemicalBook CAS DataBase List THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID

THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID synthesis

4synthesis methods

Product Name:THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
CAS Number:59944-76-2
Molecular formula:C8H5NO2S
Molecular Weight:179.2

154650-88-1 Synthesis

Methyl thieno[2,3-b]pyridine-2-carboxylate

154650-88-1
33 suppliers
$120.18/1gm:

59944-76-2
70 suppliers
$27.00/250mg

Yield:59944-76-2 85%

Reaction Conditions:

with hydrogenchloride;sodium hydroxide in methanol;water;

Steps:

12.v N-(1-azabicyclo[2.2.1]hept-3-yl)-thieno[2,3-b]pyridine-2-carboxamide

C101 (0.700 g, 3.63 mmol) is dissolved in MeOH (15 mL) and 3 mL H₂O. 2N NaOH (1.82 mL, 3.63 mmol) is added drop-wise, and the reaction is stirred at rt for 24 h. The reaction is concentrated in vacuo, and H₂O (40 mL) is added to dissolve the residue. The resulting solution is acidified to pH 4 using concentrated HCl, and the precipitate is isolated by filtration, yielding thieno[2,3-b]pyridine-2-carboxylic acid (C102) as a white powder (85% yield). MS (EI) for C₈H₅NO₂S, M/z: 179 (M)⁺.

References:

US2003/153595,2003,A1

59944-78-4 Synthesis

ETHYL THIENO[2,3-B]PYRIDINE-2-CARBOXYLATE

59944-78-4
41 suppliers
$85.00/500mg

59944-76-2
70 suppliers
$27.00/250mg

References

ETHYL 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE

52505-46-1
93 suppliers
$20.00/1g

59944-76-2
70 suppliers
$27.00/250mg

References

36404-88-3 Synthesis

36404-88-3
315 suppliers
$5.00/1g

59944-76-2
70 suppliers
$27.00/250mg

References

THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Related Search:

Thieno[3,2-b]thiophene-2-carbonitrile Thieno[2,3-b]pyrazine THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Thieno[2,3-c]pyridine-2-carboxylic acid (9CI) Thieno[3,2-c]pyridine-2-carboxylic acid Thieno[2,3-b]pyridine (8CI,9CI) Thieno[2,3-b]pyridine-5-carboxylic acid THIENO[2,3-B]QUINOLINE-2-CARBOXYLIC ACID Thieno[2,3-c]pyridine-2-carboxaldehyde (9CI) Thieno[3,2-b]pyridine-6-carbonitrile (9CI)