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Thieno[2,3-d]pyrimidin-4(1H)-one, 2-propyl- synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 12 h / 25 °C
2: sodium hydroxide / 1 h / Reflux

References:

Theoclitou, Maria-Elena;Aquila, Brian;Block, Michael H.;Brassil, Patrick J.;Castriotta, Lillian;Code, Erin;Collins, Michael P.;Davies, Audrey M.;Deegan, Tracy;Ezhuthachan, Jayachandran;Filla, Sandra;Freed, Ellen;Hu, Haiqing;Huszar, Dennis;Jayaraman, Muthusamy;Lawson, Deborah;Lewis, Paula M;Nadella, Murali V. P.;Oza, Vibha;Padmanilayam, Maniyan;Pontz, Timothy;Ronco, Lucienne;Russell, Daniel;Whitston, David;Zheng, Xiaolan [Journal of Medicinal Chemistry,2011,vol. 54,# 19,p. 6734 - 6750]