thieno[3,2-b]pyridine-6-carbaldehyde synthesis

Yield:117390-35-9 61%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;magnesium oxide in ethanol at 20; for 12 h;

Steps:

141B Example 14 - thienor3,2-b1pyridine-6-carba (B-243)

A suspension of compound B-242 (1.0 g, 5.1 mmol), magnesium oxide (82 mg, 2.0 mmol) and Pd/C (10%, 0.52 g) in 50 mL of ethanol was stirred at room temperature under hydrogen atmosphere for 12 hours. On completion, the reaction mixture was filtered, and the filtrate was concentrated and purified by silica gel chromatography [petroleum ether: ethyl acetate = 2: 1] to give compound B-243 (0.50 g, 61% yield) as a yellow solid. LCMS: (ES⁺) m/z (M+H)⁺ = 164.1 , tR=0.137.

References:

WO2015/66371,2015,A1 Location in patent:Paragraph 00482-00483