ChemicalBook CAS DataBase List thieno[3,2-g][1]benzothiophene

thieno[3,2-g][1]benzothiophene synthesis

4synthesis methods

Product Name:thieno[3,2-g][1]benzothiophene
CAS Number:211-53-0
Molecular formula:C10H6S2
Molecular Weight:190.28

19690-70-1
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211-53-0
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Yield:211-53-0 70%

Reaction Conditions:

with titanium tetrachloride;zinc in tetrahydrofuran; for 1 h;Reflux;

Steps:

I.1.2 (2) Synthesis of Sub-1-1-b

At -15 ° C, titanium tetrachloride (36.35 ml, 191.65 mmol) and zinc (8.35 g, 127.77 mmol) were added to THF (1000 ml) and refluxed for 2 hours. Subsequently, Sub-1-1-a (7.10 g, 31.94 mmol) dissolved in THF (50 ml) was slowly added thereto and refluxed for 1 hour. After the reaction is completed, the temperature of the reactant is cooled to room temperature, ice water and aqueous NaHCO 3 solution are added, extracted with EA, and washed with water. The organic layer was dried over MgSO 4, concentrated, and the concentrate was separated using a silica gel column to give 4.25 g (70%) of product

References:

KR2019/138433,2019,A Location in patent:Paragraph 0093; 0100; 0104-0105

872-31-1 Synthesis