3-Bromo-4-phenylthiophene synthesis

6synthesis methods

Product Name:3-Bromo-4-phenylthiophene
CAS Number:23062-41-1
Molecular formula:C10H7BrS
Molecular Weight:239.13

3141-26-2 Synthesis

3141-26-2
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98-80-6 Synthesis

98-80-6
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23062-41-1
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Yield:23062-41-1 96%

Reaction Conditions:

Stage #1: phenylboronic acidwith tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;sodium carbonate;triphenylphosphine in toluene at 20;Inert atmosphere;Suzuki coupling;
Stage #2: 3,4-dibromothiophene in toluene;Inert atmosphere;Suzuki coupling;
Stage #3: with sodium carbonate in toluene at 20;Inert atmosphere;Reflux;

References:

Wang, Pengcheng;Min, Jian;Nwachukwu, Jerome C.;Cavett, Valerie;Carlson, Kathryn E.;Guo, Pu;Zhu, Manghong;Zheng, Yangfan;Dong, Chune;Katzenellenbogen, John A.;Nettles, Kendall W.;Zhou, Hai-Bing [Journal of Medicinal Chemistry,2012,vol. 55,# 5,p. 2324 - 2341] Location in patent:experimental part

872-31-1 Synthesis