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ChemicalBook CAS DataBase List Tosylethyl-PE2I
1391711-43-5

Tosylethyl-PE2I synthesis

1synthesis methods
(E)-N-3-(IODOPROP-2-ENYL)2E-CARBOXY-3E-(P-TOLYL)-NORTROPAN

311351-26-5
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6315-52-2 Synthesis
1,2-BIS(TOSYLOXY)ETHANE

6315-52-2
192 suppliers
$5.00/1g

Tosylethyl-PE2I

1391711-43-5
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Yield:1391711-43-5 54%

Reaction Conditions:

Stage #1: C18H22INO2with tetra(n-butyl)ammonium hydroxide in water;toluene at 20; for 0.166667 h;
Stage #2: 1,2-bis-tosyloxyethane in acetonitrile at 20; for 2 h;

References:

Stepanov, Vladimir;Krasikova, Raisa;Raus, Liina;Loog, Olavi;Hiltunen, Jukka;Halldin, Christer [Journal of labelled compounds and radiopharmaceuticals,2012,vol. 55,# 6,p. 206 - 210] Location in patent:experimental part