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142636-23-5

Trans-2-((trimethylsilyl)ethynyl)cyclohexanol synthesis

2synthesis methods
-

Yield:142636-23-5 100%

Reaction Conditions:

Stage #1: trimethylsilylacetylenewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.166667 h;Inert atmosphere;
Stage #2: with boron trifluoride diethyl etherate in tetrahydrofuran;hexane at -78; for 0.166667 h;Inert atmosphere;
Stage #3: cyclohexane-1,2-epoxide in tetrahydrofuran;hexane at -78; for 0.5 h;Inert atmosphere;

References:

Jurberg, Igor Dias;Odabachian, Yann;Gagosz, Fabien [Journal of the American Chemical Society,2010,vol. 132,# 10,p. 3543 - 3552] Location in patent:supporting information; experimental part