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ChemicalBook CAS DataBase List TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE

TRANS-4-(TRIFLUOROMETHYL)CYCLOHEXANAMINE synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; pyridine / ethanol / 5 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

References:

Milan, Michela;Bietti, Massimo;Costas, Miquel [Organic Letters,2018,vol. 20,# 9,p. 2720 - 2723]