ChemicalBook CAS DataBase List Trifluoperazine

Trifluoperazine synthesis

1synthesis methods

Product Name:Trifluoperazine
CAS Number:117-89-5
Molecular formula:C21H24F3N3S
Molecular Weight:407.5

Trifluoperazine, 2-trifluoromethyl-10-[3-(4-methyl-1-piperazinyl) propyl]- phenothazine (6.1.5), is synthesized in the manner described above of alkylation using 2- trifluoromethylphenothazin-4-methyl-1-piperazinylpropylchloride [11,17–20].

92-30-8 Synthesis

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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 2 h / 80 °C
1.2: NaI / acetone / 48 h / Heating
2.1: K₃PO₄ / dimethylformamide / 2 h / 80 °C

References:

Madrid, Peter B.;Polgar, Willma E.;Toll, Lawrence;Tanga, Mary J. [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 11,p. 3014 - 3017]

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Trifluoperazine Related Search:

Isopropyl alcohol Cyclopropyl methyl ketone Propyl gallate Propyl butyrate 1-Methylpiperazine 2-(Trifluoromethyl)phenothiazine FLUPHENAZINE N-MUSTARD DIHYDROCHLORIDE Ftormetazine trifluoperazine sulfoxide