tris(4-isopropylphenyl) phosphate synthesis
- Product Name:tris(4-isopropylphenyl) phosphate
- CAS Number:2502-15-0
- Molecular formula:C27H33O4P
- Molecular Weight:452.52
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Yield:2502-15-0 87%
Reaction Conditions:
Stage #1: 4-Isopropylphenolwith potassium phosphate;diphenyl diselenide;phosphorus in dimethyl sulfoxide;toluene at 60; for 4 h;Inert atmosphere;
Stage #2: with dihydrogen peroxide in dimethyl sulfoxide;toluene at 20; for 0.5 h;Inert atmosphere;
Steps:
32 Example 32: Preparation of Triisopropylphenyl Phosphate
In a 10mL reaction flask, first add K3PO4 (0.045mmol, 9.6mg), diphenyl diselenide (0.045mmol, 14.1mg),White phosphorus in toluene solution (white phosphorus 5.6mg, toluene 0.5mL), p-isopropyl phenol (1.1mmol, 163.0mg), dimethyl sulfoxide (0.5mL, under argon conditions, heated to 60, after 4h reaction,The reaction solution was cooled to room temperature, hydrogen peroxide (0.5 mL) was added, and the mixture was stirred at room temperature for 30 min. The reaction was stopped as determined by the phosphorus spectrum.The reaction solution was extracted with ethyl acetate, then concentrated and separated by column chromatography to obtain 70.9 mg of triisopropylphenyl phosphate, with a yield of 87%
References:
CN113004323,2021,A Location in patent:Paragraph 0071-0073
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