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ChemicalBook CAS DataBase List Tris(hydroxymethyl)aminomethane
77-86-1

Tris(hydroxymethyl)aminomethane synthesis

3synthesis methods
Tris is prepared industrially by the exhaustive condensation of nitromethane with formaldehyde under basic conditions (i.e. repeated Henry reactions) to produce the intermediate (HOCH2)3CNO2, which is subsequently hydrogenated to give the final product.
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Yield:-

Steps:

Materials

40% Acrylamide:bisacrylamide solution (19:1)
Tris base
Boric acid (H3BO3)
Urea

References:

Walker, Sarah E.;Lorsch, Jon [Methods in Enzymology,2013,vol. 529,p. 171 - 184]

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