Lefamulin acetate synthesis
- Product Name:Lefamulin acetate
- CAS Number:1350636-82-6
- Molecular formula:C30H49NO7S
- Molecular Weight:567.78
5709-98-8
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Yield:-
Steps:
Multi-step reaction with 8 steps
1.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.58 h / 20 - 95 °C / Reflux
2.1: copper(l) chloride / 0.83 h / 80 - 100 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 15 - 40 °C / Industry scale
4.1: tetrabutyl-ammonium chloride / toluene / 4 h / 30 - 45 °C / Industry scale
5.1: hydrazine hydrate; DL-dithiothreitol / dichloromethane / 3 h / 18 - 22 °C / Industry scale
6.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale
7.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale
7.2: 1.5 h / 0 - 25 °C / Industry scale
8.1: acetic acid methyl ester; water / 4.08 h / 0 - 55 °C
References:
WO2011/146954,2011,A1
31716-01-5
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4771-80-6
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1350636-88-2
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![tert-butyl N-[(1R)-cyclohex-3-en-1-yl]carbamate](/CAS/20200401/GIF/1350636-87-1.gif)
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