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1142015-13-1

YWQUROWPKWKDNA-APHAIJBRSA-N synthesis

7synthesis methods
Dimethyl P-[(1E,3S)-3-amino-3-(hydroxymethyl)-5-(4-octylphenyl)-1-penten-1-yl]phosphonate

1142015-24-4
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YWQUROWPKWKDNA-APHAIJBRSA-N

1142015-13-1
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Yield:1142015-13-1 100%

Reaction Conditions:

Stage #1: (S,E)-dimethyl 3-amino-3-(hydroxymethyl)-5-(4-octylphenyl)pent-1-enylphosphonatewith trimethylsilyl bromide in dichloromethane;Inert atmosphere;
Stage #2: with methanolInert atmosphere;

References:

Liu, Zheng;Macritchie, Neil;Pyne, Susan;Pyne, Nigel J.;Bittman, Robert [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 9,p. 2503 - 2510]