Z-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH synthesis

9synthesis methods

Product Name:Z-N-(N-BETA-BOC-AMINOETHYL)-GLY-OH
CAS Number:34046-07-6
Molecular formula:C17H24N2O6
Molecular Weight:352.38

Glycine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-N-[(phenylmethoxy)carbonyl]-, ethyl ester

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34046-07-6
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Yield:34046-07-6 99%

Reaction Conditions:

with water;lithium hydroxide in tetrahydrofuran;methanol;water at 20; for 18 h;

Steps:

At 4°C, LiOH H₂0 (6.36 g, 152 mmol) was added to a soln of 27 (28.82 g, 75.8 mmol) in MeOH (86 mL), H₂0 (85 mL) and THF (270 mL). The mixture was stirred for 18 h at rt, acidified with 1 M aq. HCI soln (500 mL) and extracted with EtOAc. The organic phase was dried (Na₂S0₄), filtered and concentrated to give 123 (26.5 g, 99%).

References:

WO2013/139697,2013,A1 Location in patent:Page/Page column 129

24123-14-6 Synthesis