ZEARALANONE synthesis

Yield:5975-78-0 96%

Reaction Conditions:

with Pd/C;hydrogen in ethanol at 20;

Steps:

2.6General Procedure for Hydrogenation
General procedure: To a solution of zearalenonederivative (1.0 equiv) in EtOH (0.012 M) was added Pd/C (5 wt.%, 4 or 5 mol%).The mixture was stirred at room temperature under H₂ atmosphere.After completion of the reaction, it was filtered through a pad of Celite,washed with EtOAc and concentrated in vacuo. Purification of the cruderesidue by column chromatography gave the pure hydrogenated compound.

References:

Tadpetch, Kwanruthai;Kaewmee, Benyapa;Chantakaew, Kittisak;Kantee, Kawalee;Rukachaisirikul, Vatcharin;Phongpaichit, Souwalak [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 15,p. 3612 - 3616] Location in patent:supporting information

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