| Identification | More | [Name]
3-Amino-4-hydroxybenzoic acid | [CAS]
1571-72-8 | [Synonyms]
3-AMINO-4-HYDROXYBENZOIC ACID
4-HYDROXY-3-AMINOBENZOIC ACID
BENZOIC ACID, 3-AMINO-4-HYDROXY-
TIMTEC-BB SBB006740
3-Amino-4-hydroxybenzoic acid 97%
3-Amino-4-hydroxybenzoic acid, HPLC 98%
3-AMINO-4-HYDROXYBENZOIC ACID USP
3-amino-4-hydroxybenzenecarboxylic acid | [EINECS(EC#)]
216-390-2 | [Molecular Formula]
C7H7NO3 | [MDL Number]
MFCD00007697 | [Molecular Weight]
153.14 | [MOL File]
1571-72-8.mol |
| Chemical Properties | Back Directory | [Appearance]
beige-grey to brown crystalline powder | [Melting point ]
208 °C (dec.) (lit.) | [Boiling point ]
276.03°C (rough estimate) | [density ]
1.3585 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Soluble in solvents. | [form ]
Crystalline Powder | [pka]
9.06±0.18(Predicted) | [color ]
Beige-gray to brown | [Sensitive ]
Light Sensitive | [λmax]
308nm(H2O (pH 11))(lit.) | [BRN ]
972238 | [InChI]
InChI=1S/C7H7NO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9H,8H2,(H,10,11) | [InChIKey]
MRBKRZAPGUCWOS-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC=C(O)C(N)=C1 | [CAS DataBase Reference]
1571-72-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, AIR SENSITIVE, LIGHT SENSITIVE | [HS Code ]
29225090 |
| Hazard Information | Back Directory | [Chemical Properties]
beige-grey to brown crystalline powder | [Application]
3-Amino-4-hydroxybenzoic acid is the first matrix to be used specifically for carbohydrates. The other most commonly used matrices are α-cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid, and sinapinic acid. Matrix and sample solutions are mixed prior to laser exposure, spotted on a solid metallic surface, and allowed to dry before submitting them to MALDI. These matrices are characterized by high absorptivity of the laser radiation and the capability of forming fine crystalline solids during sample/matrix drying. In general, the more fine-grained and homogeneous the morphology of crystals formed with the analyte/matrix mixture, the more intense the MALDI mass spectrum of the analyte. 3-Amino-4-hydroxybenzoic acid produced [M+Na]+ ions from as little as 1 pmol of dextran hydrolysate and N-linked glycans released from glycoproteins.
| [Uses]
3-Amino-4-hydroxybenzoic acid is used to produce 4-acetoxy-3-acetylamino-benzoic acid with acetic acid anhydride at temperature of 0 - 20°C. This reaction will need reagents aq. HCl and NaOAc. | [Definition]
ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid carrying an additional amino substitutent at position 3. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 54, p. 3740, 1989 DOI: 10.1021/jo00276a044 |
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