NPS 2143
- CAS No.
- 284035-33-2
- Chemical Name:
- NPS 2143
- Synonyms
- CS-276;CS-1600;NPS 2143;SB262470;SB 262470A;NPS-2143 base;NPS-2143 NPS2143;NPS 2143 USP/EP/BP;SB-262470(NPS-2143);NPS-2143 (SB-262470)
- CBNumber:
- CB01512638
- Molecular Formula:
- C24H25ClN2O2
- Molecular Weight:
- 408.92
- MDL Number:
- MFCD04113010
- MOL File:
- 284035-33-2.mol
| Boiling point | 608.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| solubility | ≥40.9 mg/mL in DMSO; insoluble in H2O; ≥28.35 mg/mL in EtOH |
| form | Powder |
| pka | 13.67±0.20(Predicted) |
| FDA UNII | Z25PJ77W7V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
NPS 2143 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 3626 | NPS2143 hydrochloride ≥99%(HPLC) | 284035-33-2 | 50 | $908 | 2021-12-16 | Buy |
| Usbiological | 256031 | NPS 2143 hydrochloride | 284035-33-2 | 10mg | $466 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0029514 | 2-CHLORO-6-[(2R)-3-[[1,1-DIMETHYL-2-(2-NAPHTHALENYL)ETHYL]AMINO]-2-HYDROXYPROPOXY]BENZONITRILE 95.00% | 284035-33-2 | 5MG | $505.71 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181069 | NPS-2143(SB 262470A ) >98% | 284035-33-2 | 100mg | $578 | 2021-12-16 | Buy |
| ChemScene | CS-0319 | NPS-2143 99.34% | 284035-33-2 | 100mg | $660 | 2021-12-16 | Buy |
NPS 2143 Chemical Properties,Uses,Production
Uses
NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.
Biological Activity
nps-2143 is a novel and selective antagonist of casr (ca2+-sensing receptor) with the ec50 value of 4.27mm for [ca2+]o [1].calcilytics nps-2143 has been reported to diminish the sensitivity of the casr for [ca2+]o, resulting in an attenuated signal transduction in vitro and increased secretion of pth in vivo. in addition, the ec50 values of nps-2143 are 4.27, 1.56, 1.61, 2.46, 2.07 and 3.15mm for the wild-type casr, mutant casr (t151r, p221l, e767q, g830s, and a844t), respectively. apart from these, in hek 293t cells expressing casr, nps-2143 has been revealed to inhibit the [ca2+]o-induced cytosolic calcium signal in a concentration-dependent manner [1]..
target
Ca(2+) receptor
References
[1] letz s1, rus r, haag c, dörr hg, schnabel d, möhlig m, schulze e, frank-raue k, raue f, mayr b, schöfl c. novel activating mutations of the calcium-sensing receptor: the calcilytic nps-2143 mitigates excessive signal transduction of mutant receptors. j clin endocrinol metab. 2010 oct;95(10):e229-33.
NPS 2143 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 | sales@runyanpharma.com | China | 326 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
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