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Afzelin

Afzelin structure

CAS No.: 482-39-3

Chemical Name:: Afzelin

Synonyms: AFZELIN;KaeMpferin;KAEMPFEROL 3-O-RHAMNOSIDE;Afzeloside;Kaempferol 3-rhamnoside;Kaempferol 3-O-α-L-Rhamnoside;KAEMPFEROL 3-O-GLUCORHAMNOSIDE;KAEMPFERIN; KAEMPFEROL-3-RHAMNOSIDE;Afzelin/Kaempferol 3-o-glucorhamnoside;3-(α-L-Rhamnopyranosyloxy)-5,7,4'-trihydroxyflavone

CBNumber:: CB6321426

Molecular Formula:: C21H20O10

Molecular Weight:: 432.38

MDL Number:: MFCD00210589

MOL File:: 482-39-3.mol

MSDS File:: SDS

Last updated:2024-05-29 15:34:05

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Afzelin Properties

Melting point	172-174 °C (decomp)(Solv: water (7732-18-5))
Boiling point	765.6±60.0 °C(Predicted)
Density	1.70±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in methan
form	powder
pka	6.20±0.40(Predicted)
color	Yellow
FDA UNII	5M86W1YH7O

Afzelin price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	300520	Kaempferin	482-39-3	10mg	$433	2021-12-16	Buy
TRC	K100005	Kaempferol3-O-α-L-Rhamnoside	482-39-3	25mg	$1540	2021-12-16	Buy
AK Scientific	W1662	Afzelin	482-39-3	5mg	$725	2021-12-16	Buy
Biosynth Carbosynth	FK72069	Kaempferol-3-O-rhamnoside	482-39-3	5mg	$500	2021-12-16	Buy
Biorbyt Ltd	orb594646	Kaempferol-3-O-glucorhamnoside	482-39-3	20mg	$513.4	2021-12-16	Buy

Product number	Packaging	Price	Buy
300520	10mg	$433	Buy
K100005	25mg	$1540	Buy
W1662	5mg	$725	Buy
FK72069	5mg	$500	Buy
orb594646	20mg	$513.4	Buy

Afzelin Chemical Properties,Uses,Production

Description

Afzelin (Synonyms: Kaempferol-3-O-rhamnoside) is a flavonoid isolated from Thesium chinense Turcz. and widely distributed in Korea and China. It has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis Induced cardiotoxicity and scopolamine -induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin.

Uses

Kaempferol 3-O-α-L-Rhamnoside is found in Cornus macrophylla and has shown to have antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals.

Definition

ChEBI: Afzelin is a glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage. It has a role as a plant metabolite, an antibacterial agent and an anti-inflammatory agent. It is a glycosyloxyflavone, a trihydroxyflavone and a monosaccharide derivative. It is functionally related to a kaempferol. It is a conjugate acid of an afzelin(1-).

References

[1] SO-YOUNG OH. Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia.[J]. Scientific Reports, 2021: 9182. DOI:10.1038/s41598-021-88463-6.
[2] LEI XIA. Afzelin induces immunogenic cell death against lung cancer by targeting NQO2.[J]. BMC Complementary Medicine and Therapies, 2023, 23 1: 381. DOI:10.1186/s12906-023-04221-3.
[3] EVA RACHMI. Identification of afzelin potential targets in inhibiting triple-negative breast cancer cell migration using reverse docking.[J]. Porto biomedical journal, 2020, 5 6: e095. DOI:10.1097/j.pbj.0000000000000095.
[4] SIMPLICE JOEL NDENDOUNG TATSIMO. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum.[J]. BMC Research Notes, 2012, 5: 158. DOI:10.1186/1756-0500-5-158.
[5] YOUNG-KYOON KIM. Isolation of flavonol rhamnosides fromloranthus tanakae and cytotoxic effect of them on human tumor cell lines[J]. Archives of Pharmacal Research, 2004, 27 1: 44-47. DOI:10.1007/BF02980044.
[6] VINIT RAJ. Antiviral activities of 4H-chromen-4-one scaffold-containing flavonoids against SARS–CoV–2 using computational and in vitro approaches[J]. Journal of Molecular Liquids, 2022, 353: Article 118775. DOI:10.1016/j.molliq.2022.118775.
[7] BORBáLA VERMES . The synthesis of afzelin, paeonoside and kaempferol 3-O-β-rutinoside[J]. Phytochemistry, 1976, 15 8: Pages 1320-1321. DOI:10.1016/0031-9422(76)85106-0.

Afzelin Preparation Products And Raw materials

Raw materials

Preparation Products

Afzelin Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	chem1022@hengdian-group.com	China	1478	58

Supplier	Advantage
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Hubei xin bonus chemical co. LTD	58
Shanghai Standard Technology Co., Ltd.	58
career henan chemical co	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Apeloa Pharmaceutical Co., Ltd.	58

View Lastest Price from Afzelin manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-02-24	Afzelin 482-39-3	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
	2020-01-19	KAEMPFEROL 3-O-GLUCORHAMNOSIDE 482-39-3	US $3.00 / KG	1KG	98%	1kg,5kg,50kg	Career Henan Chemical Co

Afzelin
482-39-3
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

KAEMPFEROL 3-O-GLUCORHAMNOSIDE
482-39-3
US $3.00 / KG
98%
Career Henan Chemical Co

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KAEMPFEROL 3-O-GLUCORHAMNOSIDE 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl α-L-rhamnopyranoside 3-(α-L-Rhamnopyranosyloxy)-5,7,4'-trihydroxyflavone 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one KAEMPFERIN; KAEMPFEROL-3-RHAMNOSIDE 4H-1-Benzopyran-4-one,3-[(6-deoxy-a-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- Afzelin/Kaempferol 3-o-glucorhamnoside Kaempferol 3-O-α-L-Rhamnoside AFZELIN KAEMPFEROL 3-O-RHAMNOSIDE Kaempferol 3-rhamnoside KaeMpferin Afzeloside PTEN,MMAC1,Afzelin,Phosphatase and tensin homolog,inhibit,Autophagy,Inhibitor,Bacterial,Mitochondrial Metabolism 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one 482-39-3