Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
화학적 성질
White to off-white powder
용도
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
정의
ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
일반 설명
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Safety Profile
Moderately toxic by
intraperitoneal route. An experimental
teratogen. When heated to decomposition it
emits toxic fumes of Nox
Purification Methods
Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]