ChemicalBook >제품 카탈로그 >N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드 구조식 이미지

카스 번호:: 212631-61-3

한글명:: N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드

동의어(한글):: N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드

상품명:: N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-METHYLPHENYL)AMINO]-BENZAMIDE

동의어(영문):: PD 198306;N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-(4-iodo-2-methylanilino)benzamide;N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-METHYLPHENYL)AMINO]-BENZAMIDE;Benzamide, N-(cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-;MAPK,inhibit,neuropathic,Inhibitor,MAP2K,rabies,mitogen-activated protein,drug,MAPKK,PD-198306,phosphatases,PD 198306,inositol,RNA,pain,interference,MEK,ERK,antihyperalgesic,screening,Mitogen-activated protein kinase kinase,phosphate,kinases,PD198306

CBNumber:: CB72448962

분자식:: C18H16F3IN2O2

포뮬러 무게:: 476.23

MOL 파일:: 212631-61-3.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 31

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드 속성

녹는점: 125-127 °C

밀도: 1.686±0.06 g/cm3(Predicted)

저장 조건: Store at +4°C

용해도: DMSO에 용해됨

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): -3.95±0.50(Predicted)

색상: 하얀색

안전

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드 C화학적 특성, 용도, 생산

개요

PD 198306 is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC₅₀ = 8 nM). It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC₅₀s = >1 μM). PD 198306 (3-100 μM) reduces ERK1/2 phosphorylation and inhibits growth of HL-60 cells in vitro. In vivo, PD 198306 (10-30 mg/kg) reduces ERK1/2 phosphorylation and matrix metalloproteinase-1 (MMP-1) expression in a dose-dependent manner in a rabbit model of osteoarthritis. It also reduces ERK1/2 activity in the lumbar spinal cord and blocks static allodynia in rat models of neuropathic pain induced by streptozotocin or chronic constriction injury.

용도

PD 198306 is a cell-permeable and highly selective potent inhibitor of MEK 1/2.

생물학적 활성

Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30-100 nM. Highly selective for MEK; IC 50 values are > 1, > 4, > 4 and > 10 μ M for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드 준비 용품 및 원자재

원자재

준비 용품

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드 공급 업체

글로벌( 31)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3688	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58

N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-메틸페닐)아미노]-벤자미드 관련 검색:

Benzenemethanamine, 2-amino-4-fluoro- (9CI) 3-FLUORODIPHENYLAMINE 2-AMINO-5-FLUOROBENZAMIDE N-(CYCLOPROPYLMETHOXY)-3,4,5-TRIFLUORO-2-[(4-IODO-2-METHYLPHENYL)AMINO]-BENZAMIDE 4-fluoro-N-hydroxybenzamide