P-클로로아닐린
|
|
P-클로로아닐린 속성
- 녹는점
- 67-70 °C (lit.)
- 끓는 점
- 232 °C (lit.)
- 밀도
- 1,43 g/cm3
- 증기 밀도
- 4.4 (vs air)
- 증기압
- 0.15 mm Hg ( 25 °C)
- 굴절률
- 1.5546
- 인화점
- 120°C
- 저장 조건
- Store below +30°C.
- 용해도
- 2.2g/L
- 물리적 상태
- 결정질 고체
- 산도 계수 (pKa)
- 4.15(at 25℃)
- 색상
- 베이지~갈색-보라색
- Specific Gravity
- 1.2417
- 냄새
- 달콤한
- pH 범위
- 6.9 at 1.00000 g/l at 20 °C
- 수소이온지수(pH)
- 6.9 (1g/l, H2O, 20℃)
- 수용성
- 0.3g/100mL(20℃)
- Merck
- 14,2118
- BRN
- 471359
- Henry's Law Constant
- 1.07 at 25 °C (calculated, Howard, 1989)(x 10-5 atm?m3/mol)
- 안정성
- 안정적인. 타기 쉬운. 강산화제, 산, 산 염화물, 산 무수물, 클로로포르메이트, 아질산과 호환되지 않습니다. 빛에 민감할 수 있습니다.
- LogP
- 1.83 at 25℃
- CAS 데이터베이스
- 106-47-8(CAS DataBase Reference)
- IARC
- 2B (Vol. 57) 1993
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,N,F | ||
---|---|---|---|
위험 카페고리 넘버 | 45-23/24/25-43-50/53-52/53-39/23/24/25-11-51/53 | ||
안전지침서 | 53-45-60-61-36/37-16-7 | ||
유엔번호(UN No.) | UN 2018 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | BX0700000 | ||
F 고인화성물질 | 8-10-23 | ||
자연 발화 온도 | 685 °C | ||
위험 참고 사항 | Toxic/Possible Carcinogen | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29214210 | ||
유해 물질 데이터 | 106-47-8(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 0.31 g/kg (Smyth) | ||
기존화학 물질 | KE-05525 |
P-클로로아닐린 C화학적 특성, 용도, 생산
화학적 성질
4-Chloroaniline is a colourless to slightly amber-coloured crystalline solid with a mild aromatic odour. It is Soluble in hot water and organic solvents. 4-Chloroaniline has a moderate vapour pressure and n-octanol/ water partition coefficient. It decomposes in the presence of light and air and at elevated temperatures.물리적 성질
Yellowish-white solid with a mild, sweetish odor. Odor threshold concentration is 287 ppm (quoted, Keith and Walters, 1992).용도
4-Chloroaniline is an important raw material in production of agricultural chemicals, azo dyes and pigments, cosmetics, and pharmaceutical products. It is used as an intermediate in the manufacture of chromophore AS-LB, as well as in pharmaceutical intermediates such as chlordiazepoxide and phena tincture. It is also an intermediate for the herbicide Anilofos, the insecticide chlorbenzuron and the plant growth regulator Inabenfide.제조 방법
synthesis of 4-Chloroaniline: p-chloronitrobenzene is used as raw material, Raney nickel is used as catalyst, ethanol is used as solvent, reaction temperature is 50~70°C , hydrogenation pressure is 3.04~3.55MPa, and medium pH=5~6 conditions, carry out Catalytic hydrogenation reaction to obtain 4-Chloroaniline.주요 응용
4-Chloroaniline is an important building block used in the chemical industry for the production of drugs and dyestuffs. Some benzodiazepine drugs use 4-chloroaniline in their manufacture.정의
ChEBI: 4-chloroaniline is a chloroaniline in which the chloro atom is para to the aniline amino group. It is a chloroaniline and a member of monochlorobenzenes.일반 설명
P-chloroaniline appears as a white or pale yellow solid. Melting point 69.5°C.공기와 물의 반응
Insoluble in cold water. Soluble in hot water [Hawley].반응 프로필
4-Chloroaniline is incompatible with oxidizing agents. Also incompatible with acids, acid chlorides, acid anhydrides and chloroformates. Subject to exothermic decomposition during high-temperature distillation. Incompatible with nitrous acid.위험도
Toxic by inhalation and ingestion. Possible carcinogen.건강위험
Inhalation or ingestion causes bluish tint to fingernails, lips, and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.화재위험
Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride and oxides of nitrogen may form in fires.Safety Profile
Confirmed carcinogen with experimental neoplastigenic and tumorigenic data. Poison by ingestion, inhalation, sh contact, subcutaneous, and intravenous routes. A skin and severe eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also ANILINE DYESPurification Methods
Crystallise the aniline from MeOH, pet ether (b 30-60o), or 50% aqueous EtOH, then *benzene/pet ether (b 60-70o), and then dry it in a vacuum desiccator. It can be distilled under vacuum (b 75-77o/3mm). It sublimes in a very high vacuum. The acetate crystallises from aqueous MeOH (m 178o, 180o) or EtOH or AcOH (m 173-174o) and has b 331.3o/760mm. [Beilstein 12 III 1325, 12 IV 1116.]P-클로로아닐린 준비 용품 및 원자재
원자재
준비 용품
이미다졸-2-일아민설페이트
신토펜
2-아미노-5-클로로-디페닐메탄올
1-클로로-4-이소시아노벤젠
2- 아미노 -5- 클로로 벤조
(4-클로로페닐)하이드라진
polyaniline synthesized by means of condensation polymerization
6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID
클로헥시딘다이아세테이트
2-아미노-5-클로로-2'-플루오로벤조페논
Tenidap
2,6-Dichlorobenzothiazole
N-(2-[4-(4-CHLOROPHENYL)PIPERAZIN-1-YL]ETHYL)-3-METHOXYBENZAMIDE
5-클로로오르타닐산
나프톨AS-E
1-(4-클로로페닐)피페라진
4-CHLORO-(N-BOC)ANILINE 97
N-(4-클로로페닐)-2-히드록시-9H-카르바졸-3-카르복사미드
FLURAZEPAM
아닐로포스
4-클로로페닐 이소시안산
에파비렌즈
M-클로로페놀
4-(4-(클로로페닐)이미노)-1-이소프로필피페리딘
디플루벤주론
Nitrazepam
Chlorhexidine diacetate
Lorcainide
chlorbenzuron
6-클로로-2-메틸렌놀린
5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
클로플루카반
N-(4-클로로페닐)-1-이소프로필피페리딘-4-아민
P-클로로아닐린 공급 업체
글로벌( 538)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 |
sales@richfortunechem.com | China | 304 | 57 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9340 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32715 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |