메틸(1-)-4-피페리돈
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메틸(1-)-4-피페리돈 속성
- 녹는점
- 192-193 °C(Solv: ethyl acetate (141-78-6))
- 끓는 점
- 55-60 °C11 mm Hg(lit.)
- 밀도
- 0.92 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.460
- 인화점
- 140 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
- 용해도
- 클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨
- 산도 계수 (pKa)
- 8.02±0.20(Predicted)
- 물리적 상태
- 액체
- Specific Gravity
- 0.92
- 색상
- 맑은 노란색에서 주황색으로
- 수소이온지수(pH)
- 12 (100g/l, H2O, 20℃)
- 수용성
- 혼용 가능
- 감도
- Air Sensitive
- BRN
- 106924
- CAS 데이터베이스
- 1445-73-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 34-10-36/37/38 | ||
안전지침서 | 23-24/25-37/39-26 | ||
유엔번호(UN No.) | UN 1224 3/PG 3 | ||
WGK 독일 | 3 | ||
위험 참고 사항 | Irritant | ||
위험 등급 | 3 | ||
포장분류 | III | ||
HS 번호 | 29333999 |
메틸(1-)-4-피페리돈 C화학적 특성, 용도, 생산
화학적 성질
clear yellow to orange liquid용도
1-Methyl-4-piperidone, are widely used in artificial fibre industry. They are polymerizable and used as nylon precursors. They have excellent applications as solvents and as intermediates for organic synthesis. They are used in the aqueous carrier medium and amide penetrants in inks and water soluble paints.주요 응용
N-Methyl-4-piperidone can be used as a reactant to prepare:Spiropiperidine rings by reacting with malononitrile and electrophiles or Michael acceptors.
(3E,5E)-1-Methyl-3,5-bis(phenylmethylene)-4-piperidinone by reacting with benzaldehyde via Michael addition, followed by intramolecular O-cyclization/elimination sequential reactions.
N,N′-Dimethylbispidinone by utilizing a double Mannich condensation method.
제조 방법
[JACS (1948) vol 70 p 1820] for the synthesis of 1-methyl-4-piperidone:To a one-liter flask containing 350 ml of 20 % hydrochloric acid was added 86 g. of 1-methyl-3-carbethoxy-4-piperidone hyrdrochloride. After refluxing for one hour, the ferric chloride reagent gave no coloration. The solution was evaporated to dryness on a steam-bath at 10 mm. pressure. The solid product, heated at 100 °C for 4 hours at 0.1 mm and further dried over solid KOH for 24 hours, weighed 57.7 g, m.p. 80 - 120 °C.
Although this melting range goes above that of the pure comound 0.45 of crude material dissolved in 90 ml. of hot acetone gave 0.40 g of pure compoundd melting at 93 - 95 °C. Other samples of crude piperidone hydrochloride showed even higher melting points than the one mentioned above, yet this apperently impure material always gave good yields of sharp melting product when recrystallized.
Purification Methods
It is best purified by fractional distillation The hydrochloride of the hydrate (4-diol) has m 94.7-95.5o, but the anhydrous hydrochloride which crystallises from CHCl3/Et2O has m 165-168o (164-167o) and can also be obtained by sublimation at 120o/2mm. The oxime has m 130-132o (from Me2CO). The methiodide crystallises from MeOH, the crystals with 1MeOH have m 189-190o, and the solvent-free iodide has m 202-204o(dec). [Lyle et al. J Org Chem 24 342 1959, Bowden & Greeen J Chem Soc 1164 1952, Tomita Yakugaku Zasshi (J Pharm Soc Japan) 71 1053 1951, Beilstein 21 IIII/IV 3183, 21/6 V 419.]메틸(1-)-4-피페리돈 준비 용품 및 원자재
원자재
준비 용품
N-메틸-3-카보메톡시-4-피페리돈염산염
4-클로로-N-메틸피페리딘
2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE
N-메틸-4-피페리디놀
5-메틸-4,5,6,7-테트라히드로티아졸로[5,4-c]피리딘-2-카르복실산염산염
5-BENZYL-2-METHYL-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE
ETHYL 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE-3-CARBOXYLATE
5,6,7,8-테트라히드로-6-메틸-1,6-나프티리딘-3-아민
4-메틸렌피페리딘
피리딘,4,4'-[1,1'-비페닐]-4,4'-DIYLBIS-
5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE
4-CHLORO-3-IODOPYRIDINE
N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate
1-(1-메틸-4-피페리디닐)피페라진
메틸(1-)-4-피페리돈 공급 업체
글로벌( 567)공급 업체
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Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
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