- Dothiepin
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- $50.00 / 1kg
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2024-05-29
- CAS:113-53-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000 tons
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| | Dothiepin Basic information |
| Product Name: | Dothiepin | | Synonyms: | (3E)-3-Dibenzo[b,E]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine;11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin;1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-;3-Dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-1-propamine;3-dibenzo(b,e)thiepin-11(6h)-ylidene-n,n-dimethyl-1-propanamin;3-Dibenzo[b,e]thiepin-11(6H)-ylidine-N,N-dimethyl-propanamine;Dibenzo[b,e]thiepin, 1-propanamine deriv.;Dibenzo[b,e]thiepin-delta11(6H),gamma-propylamine, N,N-dimethyl- | | CAS: | 113-53-1 | | MF: | C19H21NS | | MW: | 295.44 | | EINECS: | 204-031-2 | | Product Categories: | Chemical Amines;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds | | Mol File: | 113-53-1.mol |  |
| | Dothiepin Chemical Properties |
| Melting point | 55-57° | | Boiling point | bp0.05 171-172° | | density | 1.1022 (rough estimate) | | refractive index | 1.5300 (estimate) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Thick Oil to Low-Melting Solid | | pka | 9.35±0.28(Predicted) | | color | Off-White to Light Yellow |
| | Dothiepin Usage And Synthesis |
| Chemical Properties | Pale Yellow Low Melting Solid | | History | Described in the 1960s by the Czech company Sdruzeni Podniku pro Zdravotnickon Vyrobu; SPOFA (Spofa, 1962) | | Uses | A tricyclic antidepressant. | | Definition | ChEBI: Dothiepin is a dibenzothiepine. It has a role as an antidepressant and an anticoronaviral agent. | | Synthesis Reference(s) | Synthesis (Spofa, 1962): S-Benzylthiosalicylic acid is treated with polyphosphoric acid and the resulting cyclic ketone is reacted with 3-dimethylaminopropyl magnesium chloride to afford an alcohol which is dehydrated with sulfuric acid.
Synthesis of dosulepin | | Clinical Use | Dosulepin (also referred to as dothiepin) is a member of the TCA family and has similar clinical uses as amitrip- tyline, thus providing effective treatment of depression (Goldstein and Claghorn, 1980; Lancaster and Gonzales, 1989; Donovan et al., 1991) and also against pain (Feinmann et al., 1984; Caruso et al., 1987) and tinnitus. Like amitriptyline it has sedative properties, however its anti-muscarinic side-effects are less pronounced. Dosulepin is readily absorbed from the GI tract and extensively demethylated while undergoing a first-pass effect. Metabolic pathways include next to hydroxylation and N-oxidation steps, S-oxidation. Elimination half-lifes vary from 14 to 24 hours interindividually (Maguire et al., 1982; Yu et al., 1986; Ilett et al., 1993). |
| | Dothiepin Preparation Products And Raw materials |
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