3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers
|
| | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Basic information |
| Product Name: | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE | | Synonyms: | NICOTINAMIDE CHLOROMETHYLATE;N-METHYLNICOTINIC ACID AMIDE CHLORIDE SALT;N1-METHYLNICOTINAMIDE CHLORIDE;TRIGONELLAMIDE CHLORIDE;3-(aminocarbonyl)-1-methyl-pyridiniuchloride;3-carbamoyl-1-methyl-pyridiniuchloride;nicotinamidemethochloride;nicotinamidemethylchloride | | CAS: | 1005-24-9 | | MF: | C7H9ClN2O | | MW: | 172.61 | | EINECS: | 463-670-7 | | Product Categories: | Pyridinium Compounds | | Mol File: | 1005-24-9.mol |  |
| | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties |
| Melting point | 207-209℃ (water acetone ) | | storage temp. | room temp | | solubility | H2O: soluble15mg/mL, clear | | form | crystalline | | color | white | | Water Solubility | almost transparency | | Merck | 14,9693 | | CAS DataBase Reference | 1005-24-9(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | UU1925000 | | HS Code | 2933.39.9200 |
| | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Usage And Synthesis |
| Description | Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism. | | Uses | Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism. | | Uses | 1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC). | | General Description | 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects. | | Biochem/physiol Actions | 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT. | | Purification Methods | Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.] |
| | 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials |
|