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| | LY 294002 HYDROCHLORIDE Basic information |
| | LY 294002 HYDROCHLORIDE Chemical Properties |
| Melting point | 183-185℃ | | Boiling point | 494.6±45.0 °C(Predicted) | | density | 1.266 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: >5 mg/mL | | form | solid | | pka | 0.55±0.20(Predicted) | | color | white to off-white | | Water Solubility | Soluble in DMSO at 5mg/ml. Insoluble in water | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. | | InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N | | CAS DataBase Reference | 154447-36-6 |
| Safety Statements | 24-25 | | WGK Germany | 3 | | HS Code | 29349990 |
| | LY 294002 HYDROCHLORIDE Usage And Synthesis |
| Description | LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. | | Uses | LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). | | Uses | LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice. | | Uses | LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. | | Uses | A potent blocker of PI 3-kinase/Akt signaling. | | Definition | ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. | | Biological Activity | A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo . | | target | p110α | | References | 1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241 |
| | LY 294002 HYDROCHLORIDE Preparation Products And Raw materials |
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