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| | (R)-(-)-1-Cyclohexylethylamine Basic information |
| | (R)-(-)-1-Cyclohexylethylamine Chemical Properties |
| Melting point | -15°C (estimate) | | Boiling point | 177-178 °C (lit.) | | alpha | -3.8 º (NEAT) | | density | 0.866 g/mL at 20 °C (lit.) | | refractive index | n20/D 1.463 | | Fp | 126 °F | | pka | 10.89±0.29(Predicted) | | form | clear liquid | | color | Colorless to Almost colorless | | optical activity | [α]20/D 4°, neat &_& [α]20/D -3.8±0.3°, neat | | Water Solubility | Miscible with acetone, chloroform,dimethyl sulfoxide, ethanol, methanol, ether, petroleum ether and dichloromethane. Insoluble in water. | | Sensitive | Air Sensitive | | BRN | 2935070 | | CAS DataBase Reference | 5913-13-3(CAS DataBase Reference) | | NIST Chemistry Reference | R-(-)-Cyclohexylethylamine(5913-13-3) |
| | (R)-(-)-1-Cyclohexylethylamine Usage And Synthesis |
| Chemical Properties | optical purity >99% ee | | Uses | (R)-(-)-1-Cyclohexylethylamine may be used in the preparation of a chiral calix[4]arene Schiff base derivatives with potential enantioselective recognition ability towards amines. | | Uses | (R)-(-)-1-Cyclohexylethylamine is used in the preparation of benzylidene(1-cyclohexylethyl)amine by reacting with benzaldehyde. It is also used to prepare chiral polymethacrylamides, which are employed as stationary phases for the liquid-chromatographic resolution of racemic amides. In addition to this, it is used in the preparation of polyamides bound to silica gel for high performance liquid chromatography, which are pressure-stable. | | General Description | (R)-(-)-1-Cyclohexylethylamine is a chiral amine mainly used as a resolving agent for racemic compounds. | | Purification Methods | Purify it by conversion to the bitartrate salt (m 172o), then decomposing with strong alkali and extracting into Et2O, drying (KOH), filtering, evaporating and distilling. The hydrochloride salt has m 242o (from EtOH/Et2O), [] D -5.0o (c 10 H2O, from (+) amine). The oxalate salt has m 132o (from H2O). The (±)-base has b 176-178o/760mm, and HCl has m 237-238o. [Reihlen et al. Justus Liebigs Ann Chem 532 247 1938, Leithe Chem Ber 65 660 1932, Beilstein 12 III 95.] |
| | (R)-(-)-1-Cyclohexylethylamine Preparation Products And Raw materials |
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