- 4,4'-Dimethoxytrityl chloride
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- $8.00 / 1kg
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2024-04-05
- CAS:40615-36-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 4,4'-Dimethoxytrityl chloride Basic information |
| Product Name: | 4,4'-Dimethoxytrityl chloride | | Synonyms: | 1,1'-(chlorophenylmethylene)bis[4-methoxybenzene];4,4'-DIMETHOXY-TRIPHENYLCHLOROMETHANE;4,4'-DIMETHOXYTRIPHENYLMETHYL CHLORIDE;4,4'-DIMETHOXYTRITYL CHLORIDE;DMT-Cl (4,4-Dimethoxytrityl Chloride);4,4-Dimethoxytritylchloride98+%;Bis(4-methoxyphenyl)phenylmethyl chloride;Chlorobis(4-methoxyphenyl)phenylmethane | | CAS: | 40615-36-9 | | MF: | C21H19ClO2 | | MW: | 338.83 | | EINECS: | 255-002-6 | | Product Categories: | OLED materials,pharm chemical,electronic;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry;Regant series;Coupling Reagent;N-Protecting Reagents;Organics | | Mol File: | 40615-36-9.mol |  |
| | 4,4'-Dimethoxytrityl chloride Chemical Properties |
| Melting point | 123-125 °C | | Boiling point | 455.07°C (rough estimate) | | density | 1.0887 (rough estimate) | | vapor pressure | 0Pa at 20℃ | | refractive index | 1.5330 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Powder | | color | Pink | | Water Solubility | Soluble in chloroform and methanol. Partially soluble in water | | Sensitive | Moisture Sensitive | | BRN | 2471942 | | Stability: | Hygroscopic, Moisture Sensitive | | InChIKey | JBWYRBLDOOOJEU-UHFFFAOYSA-N | | LogP | 5.74 at 20℃ | | CAS DataBase Reference | 40615-36-9(CAS DataBase Reference) | | NIST Chemistry Reference | Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-34 | | Safety Statements | 22-24/25-37/39-26-36-45-36/37/39 | | RIDADR | 3261 | | WGK Germany | 3 | | F | 10-21 | | HS Code | 29093090 | | Toxicity | A hallucinogenic (psychedelic)
agent that may catalyze the onset of emotional problems
or psychosis in predisposed individuals. DMT is perhaps
one of the least studied of the hallucinogens. It causes perceptual
alterations and illusions, including changes in touch, taste,
and odor. The thinking process is substantially altered; there
are hallucinations and loss of contact with reality. There have
been no overdose deaths attributed to the direct effects of
DMT. The drug is very short-acting, with a duration of effect
of about half an hour or less. |
| | 4,4'-Dimethoxytrityl chloride Usage And Synthesis |
| Chemical Properties | 4,4'-Dimethoxytrityl chloride is pink powder | | Uses | 4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis | | Uses | 4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives. | | Uses | Hydroxyl protecting group for nucleosides and nucleotides. | | Flammability and Explosibility | Not classified | | Purification Methods | DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.] |
| | 4,4'-Dimethoxytrityl chloride Preparation Products And Raw materials |
| Preparation Products | 5''-O-(4,4''-Dimethoxytrityl)-inosine-->5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE-->DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)-->5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-5-METHYL-2'-DEOXYCYTIDINE-->5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ACETYL-2'-DEOXYCYTIDINE-->DMT-dG(dmf) Phosphoramidite-->N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-->5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine-->Acetamide, N-[3-[bis(4-methoxyphenyl)phenylmethoxy]-2-hydroxypropyl]-2,2,2-trifluoro--->Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], (S)- (9CI) |
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