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tolpropamine hydrochloride

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Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
Email: 1026@dideu.com
Products Intro: Product Name:tolpropamine hydrochloride USP/EP/BP
CAS:3339-11-5
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:tolpropamine hydrochloride
CAS:3339-11-5
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

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tolpropamine hydrochloride Basic information
Product Name:tolpropamine hydrochloride
Synonyms:tolpropamine hydrochloride;Einecs 222-082-9;Tolpropamine HCl;tolpropamine hydrochloride USP/EP/BP
CAS:3339-11-5
MF:C18H23N.ClH
MW:0
EINECS:222-082-9
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Mol File:Mol File
tolpropamine hydrochloride Structure
tolpropamine hydrochloride Chemical Properties
Melting point 162-164 °C
Safety Information
MSDS Information
tolpropamine hydrochloride Usage And Synthesis
OriginatorTolpropamine,Hoechst (Aventis)
Manufacturing ProcessThe Grignard solution (prepared from 53 g bromtoluene and 7.2 g magnesium in 300 ml of ether) was added dropwise to a solution of 35 g β- dimethylaminopropiophenone in 50 ml ether. The mixture was refluxed for 3 hours. Then the liquid phase was added to 500 parts of ice and 100 parts concentrated hydrochloric acid. 1-Phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was crystallized. M.P. of hydrochloride of 1-phenyl-1-p-tolyl-3- dimethylaminopropanol-1 185°C.
10 g of 1-phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was dissolved in 30 ml of 85% phosphoric acid and the solution was heated at 130-135°C for 1 hour. After cooling to the mixture was added a water and an aqueous solution of sodium hydroxide. γ-Phenyl-γ-p-tolylallyldimethylamine was extracted with ether and extract was dried with sodium sulfate. γ-Phenyl-γ-p-tolylallyldimethylamine hydrochloride was hydrogenated with palladium catalyst. γ-Phenyl-γ-p-tolyl-3-dimethylaminopropan obtained has melting point 156°C.
Therapeutic FunctionAntihistaminic, Antipruritic
tolpropamine hydrochloride Preparation Products And Raw materials
Raw materialsHydrogen
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