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| | HEXAAMMINECOBALT(III) CHLORIDE Basic information |
| | HEXAAMMINECOBALT(III) CHLORIDE Chemical Properties |
| Melting point | 217 °C(lit.) | | density | 1.71 g/mL at 25 °C(lit.) | | storage temp. | room temp | | solubility | Soluble in ammonia. | | form | Powder | | Specific Gravity | 1.71 | | color | Orange to orange-brown | | Water Solubility | Soluble in ammonia and water. | | Merck | 14,4675 | | Exposure limits | ACGIH: TWA 0.02 mg/m3 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | JXBGZYGSWFSYFI-UHFFFAOYSA-K | | CAS DataBase Reference | 10534-89-1(CAS DataBase Reference) | | EPA Substance Registry System | Cobalt(3+), hexaammine-, trichloride, (OC-6-11)- (10534-89-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | RIDADR | UN 2811 6.1/PG III | | WGK Germany | 3 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 2842908080 |
| | HEXAAMMINECOBALT(III) CHLORIDE Usage And Synthesis |
| Chemical Properties | solid | | Uses | Hexaamminecobalt(III) chloride is a component of structural biology methods, especially for DNA or RNA, where the positive ions stabilize the tertiary structure of the phosphate backbone, which favors to solve their structure by X-ray crystallography. It serves as an excellent antibacterial and antiviral property. | | Uses | As reagent for pyrophosphoric acid, for the estimation of phosphate. | | Preparation | Synthesis of hexaamminecobalt(III) chloride
2CoCl2+10NH3+2NH4Cl+H2O2 →2[Co(NH3) 6]Cl3+2H2O
Reaction. Dissolve 2.5 g (10.5 mmol) of cobalt(II) chloride hexahydrate and 1.7 g (32 mmol) of ammonium chloride (about 195% excess) in 15 mL of distilled water. Add 0.5 g of activated charcoal and 23 mL (380 mmol) of concentrated aqueous ammonia (about 624% excess). Cool the reaction mixture to 0 oC in an ice bath. Slowly add 2 mL (19.5 mmol) of 30% hydrogen peroxide (about 271% excess), with stirring – maintain the temperature below 10°C. After the hydrogen peroxide has been added, heat the reaction mixture to 60°C for about 30 minutes. Cool the reaction mixture to 0 oC to cause precipitation of the product. | | General Description | Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies. | | Purification Methods | It crystallises from warm water (8mL/g) on cooling. [Bjerrum & McReynolds Inorg Synth II 217 1946.] |
| | HEXAAMMINECOBALT(III) CHLORIDE Preparation Products And Raw materials |
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