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| Methylprednisolone sodium succinate Basic information |
Product Name: | Methylprednisolone sodium succinate | Synonyms: | 6ALPHA-METHYLPREDNISOLONE 21-HEMISUCCINATE SODIUM SALT;6-ALPHA-METHYLPREDNISOLONE SODIUM SUCCINATE;6α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate;Methylprednisolone sodium succinate (JAN/USP);6a-Methylprednisolone 21-sodium hemisuccinate;6a-Methylprednisolone 21-sodium succinate;6a-Methylprednisolone sodium hemisuccinate;6a-Methylprednisolone sodium succinate | CAS: | 2375-03-3 | MF: | C26H33O8.Na | MW: | 496.53 | EINECS: | 219-156-8 | Product Categories: | | Mol File: | 2375-03-3.mol | |
| Methylprednisolone sodium succinate Chemical Properties |
Melting point | >186°C (dec.) | storage temp. | Inert atmosphere,Room Temperature | solubility | DMSO (Slightly), Methanol (Slightly) | form | lyophilized powder | color | White to Off-White | InChIKey | FQISKWAFAHGMGT-JXAFMBTDNA-M | SMILES | [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r| | CAS DataBase Reference | 2375-03-3(CAS DataBase Reference) |
Hazard Codes | T | Risk Statements | 61-40 | Safety Statements | 53-22-36/37/39-45 | WGK Germany | 3 | RTECS | TU4154060 | Toxicity | LD50 oral in rat: > 5gm/kg |
| Methylprednisolone sodium succinate Usage And Synthesis |
Description |
Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
| Uses | 6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries. | Uses | 6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting. | Definition | ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone. | Brand name | A-Methapred (Abbott);
A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn). | Biochem/physiol Actions | Glucocorticoid with slightly longer half-life than that of prednisolone. |
| Methylprednisolone sodium succinate Preparation Products And Raw materials |
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