- N-(Trimethylsilyl)acetamide
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- $15.00 / 1KG
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2021-07-13
- CAS:13435-12-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| N-(Trimethylsilyl)acetamide Basic information |
| N-(Trimethylsilyl)acetamide Chemical Properties |
Melting point | 46-49 °C(lit.) | Boiling point | 84 °C18 mm Hg(lit.) | density | 0.859±0.06 g/cm3(Predicted) | Fp | 135 °F | storage temp. | Inert atmosphere,Room Temperature | solubility | Chloroform, DMSO, Methanol | pka | 18.23±0.46(Predicted) | form | Crystalline Mass | color | White to yellow | Water Solubility | reacts | Sensitive | Moisture Sensitive | Hydrolytic Sensitivity | 7: reacts slowly with moisture/water | BRN | 741928 | Stability: | Moisture Sensitive | CAS DataBase Reference | 13435-12-6(CAS DataBase Reference) | EPA Substance Registry System | Acetamide, N-(trimethylsilyl)- (13435-12-6) |
Hazard Codes | Xi-F,Xi,F | Risk Statements | 36/37/38-11 | Safety Statements | 37/39-26 | RIDADR | 1325 | WGK Germany | 3 | RTECS | AD0250000 | F | 10-21 | TSCA | Yes | HazardClass | 4.1 | PackingGroup | III | HS Code | 29319090 |
| N-(Trimethylsilyl)acetamide Usage And Synthesis |
Chemical Properties | WHITE TO YELLOWISH CRYSTALLINE MASS | Uses | N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670). | General Description | The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied. | Purification Methods | Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.] |
| N-(Trimethylsilyl)acetamide Preparation Products And Raw materials |
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