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| oxyfenamate Basic information |
Product Name: | oxyfenamate | Synonyms: | Al-0361;Listica;NSC-108034;P-301;(2-hydroxy-2-phenylbutyl) carbamate;(2-hydroxy-2-phenyl-butyl) carbamate;carbamic acid (2-hydroxy-2-phenyl-butyl) ester;oxyfenamate | CAS: | 50-19-1 | MF: | C11H15NO3 | MW: | 209.243 | EINECS: | 2000175 | Product Categories: | | Mol File: | 50-19-1.mol | |
| oxyfenamate Chemical Properties |
Melting point | 55-56.5° | Boiling point | 348.6°C (rough estimate) | density | 1.1547 (rough estimate) | refractive index | 1.5080 (estimate) | storage temp. | Store at -20°C | solubility | Soluble in DMSO |
Toxicity | LD50 orally in mice: 830 mg/kg (Bastian, Clements) |
| oxyfenamate Usage And Synthesis |
Originator | Listica,Armour,US,1961 | Uses | Tranquilizer (minor). | Definition | ChEBI: Oxyfenamate is an alkylbenzene. | Manufacturing Process | 2-Phenyl-2-hydroxy-butyl carbamate was prepared by the following method:
49.81 g of 2-phenyl-1,2-butanediol and 25.01 g of pyridine were dissolved in
500 ml of benzene and cooled to 5°C. 34.01 g of ethyl chloroformate was
added over a period of 36 hour at 4°C to 8°C. The reaction mixture was
warmed to room temperature and stirred for 2 hours and then extracted with
100 cc each of the following:
Water, 15% hydrochloric acid, 10% sodium bicarbonate and finally water. The
solvent was stripped off. The residual oil was mixed with 300 ml of 28%
aqueous ammonia for 1 hour. The ammonia and water were vacuum distilled
at a temperature of 40°C or less. Then 300 cc of carbon tetrachloride was
added and the solution dried with sodium sulfate. The solution was cooled at
0°C and then filtered. The crystals were washed with cold carbon tetrachloride
and vacuum dried. The yield was 57 g of dried product having a melting point
of 55°C to 56.5°C. | Therapeutic Function | Tranquilizer |
| oxyfenamate Preparation Products And Raw materials |
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