Dimethyl sulfoxide
Product identifier
- Product name: Dimethyl sulfoxide
- CBnumber: CB7854105
- CAS: 67-68-5
- EINECS Number: 200-664-3
- Synonyms: DMSO,DIMETHYL SULFOXIDE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
Substance
- Product name: Dimethyl sulfoxide
- Synonyms: DMSO,DIMETHYL SULFOXIDE
- CAS: 67-68-5
- EC number: 200-664-3
- MF: C2H6OS
- MW: 78.13
Description of first aid measures
If inhaledMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides, Sulfur oxides Combustible.
Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb? ). Dispose of properly. Clean up affected area.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Tightly closed.
Store under inert gas. hygroscopic
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsChange contaminated clothing. Wash hands after working with substance.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,2 mm Break through time: 38 min
Material tested:Dermatril? P (KCL 743 / Aldrich Z677388, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearanceclear clear, liquid
- Odourodorless
- Odour ThresholdNo data available
- pHNot applicable
- Melting point/freezing pointMelting point/range: 16 - 19 °C
- Initial boiling point and boiling range189 °C
- Flash point87 °C - closed cup - ASTM D 93
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 28,5 %(V) Lower explosion limit: 2,6 %(V)
- Vapour pressure 0,55 hPa at 20 °C
- Vapour density 2,70 - (Air = 1.0)
- Relative density1,1 g/mL
- Water solubilitycompletely miscible
- Partition coefficient: n-octanol/waterlog Pow: -1,35 at 20 °C - Bioaccumulation is not expected.
- Autoignition temperature300 - 302 °C at 1.013 hPa
- Decomposition temperature >190 °C -
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- λmaxλ: 285 nm Amax: ≤0.20
λ: 295 nm Amax: ≤0.20
Other safety information
Solubility in other solvents
Alcohol - soluble Diethyl ether - soluble
Surface tension 43,5 mN/m at 20 °C
Dissociation constant 35,1
Relative vapor density
2,70 - (Air = 1.0)
Reactivity
Forms explosive mixtures with air on intense heating.
A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
Strong heating.
Incompatible materials
Acid chlorides, Phosphorus halides, Strong acids, Strong oxidizing agents, Strong reducing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulfur oxides
Other decomposition products - No data available In the event of fire: see section 5
Information on toxicological effects
Acute toxicityLC0 Inhalation - Rat - male and female - 4 h - > 5,33 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - 40.000 mg/kg Remarks: (ECHA)
Result: slight irritation - 4 h (OECD Test Guideline 404)
Result: slight irritation - 24 h (OECD Test Guideline 405)
Local lymph node assay (LLNA) - Mouse Result: negative
(OECD Test Guideline 429)
Salmonella typhimurium Result: negative
sister chromatid exchange assay Chinese hamster ovary cells Result: negative
Mutagenicity (mammal cell test): chromosome aberration. Chinese hamster ovary cells
Result: negative
OECD Test Guideline 474 Rat - male and female Result: negative
Repeated dose toxicity - Monkey - male and female - Dermal - 18 Months - NOAEL (No observed adverse effect level) - >= 8.910 mg/kg - LOAEL (Lowest observed adverse effect level) - 990 mg/kg
RTECS: PV6210000
Exposure to large amounts can cause:, redness of skin, Itching, burning, sedation, Headache, Nausea, Dizziness
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity
static test EC50 - Daphnia magna (Water flea) - 24.600 mg/l - 48 h (OECD Test Guideline 202)
17.000 mg/l - 72 h (OECD Test Guideline 201)
(ISO 8192)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 31 % - Not readily biodegradable. (OECD Test Guideline 301D)
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available
Stability in water - 0,12 - 1,2 h at 30 °C pH 7
Remarks: Hydrolyzes readily.
Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
IncompatibilitiesDMSO reacts violently with strong oxidizers, many acyl halides, boron hydrides, and alkali metals. DMSO can form explosive mixtures with metal salts of oxoacids (sodium perchlorate, iron(III) nitrate).
Waste DisposalExcess dimethyl sulfoxide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.