| Identification | Back Directory | [Name]
HUMANIN TRIFLUOROACETATE | [CAS]
330936-69-1 | [Synonyms]
HN
HUMANIN
Humanin, HN
Humanin (1)
Humanin S14-G
HUMANIN (HUMAN)
Humanin(human) acetate
Protein humanin (human)
MAPGSGCLLLLTSEIDLPVKRRA
HUMANIN TRIFLUOROACETATE
MAPRGFSCLLLLTSEIDLPVKRRA
1-24-Protein humanin (human)
H-MAPRGFSCLLLLTSEIDLPVKRRA-OH
Humanin(human)trifluoroacetate
Drepanopeziza populorum (Desm.) Hö
Leucostoma persoonii (Nitschke) Hö
Protein (human clone 1 humanin sequence homolog)
T Lymphocyte activation-associated protein Pro86272 (human)
MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA
HNMET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA
H-MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA-OH
MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA TRIFLUOROACETATE
L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-
L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L- alpha-glutamyl-L-isoleucyl-L-alpha-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl- | [EINECS(EC#)]
200-048-4 | [Molecular Formula]
C119H204N34O32S2 | [MDL Number]
MFCD04118086 | [MOL File]
330936-69-1.mol | [Molecular Weight]
2687.27 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
solid
| [Sequence]
Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala | [InChIKey]
DPEUWKZJZIPZKE-YSUKGSMWNA-N |
| Hazard Information | Back Directory | [General Description]
Humanin (HN) is a natural short mitochondrial polypeptide with antiapoptotic and neuroprotective effects. Humanin protects cells against various diseases, including oxidative stress and cytotoxicity induced by various stimuli with broad-spectrum activity on the pancreas, brain, testis, and heart.
| [Biochem/physiol Actions]
Humanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.
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