ChemicalBook--->CAS DataBase List--->341-69-5

341-69-5

341-69-5 Structure

341-69-5 Structure
IdentificationMore
[Name]

ORPHENADRINE HYDROCHLORIDE
[CAS]

341-69-5
[Synonyms]

BF 5930
BG 5930
BS 5930
Mebedrol
Mephenamin
Brocasipal
Mephenamine
Brocadisipal
mephenaminforte
Mephenamin forte
ORPHENADRINE HCL
disipalhydrochloride
Disipal hydrochloride
orfenadrinhydrochloride
Mefenamin hydrochloride
mephenaminhydrochloride
Mephenamin hydrochloride
mephenaminehydrochloride
Orfenadrin hydrochloride
Mephenamine hydrochloride
Orph·Nadrine hydrochloride
Orphenedrine hydrochloride
ORPHENADRINE HYDROCHLORIDE
OrphenadrineHydrochloride>
Orphenadrine hydrochloride,99%
Orphenadrine hydrochloride CRS
O-METHYLDIPHENHYDRAMINE HYDROCHLORIDE
Orphenadrine hydrochloride >=98.0% (AT)
ORPHENADRINE HYDROCHLORIDE ISO 9001:2015 REACH
2-dimethylaminoethyl2-methylbenzhydryletherhydrochloride
2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE HYDROCHLORIDE
B-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER HYDROCHLORIDE
2-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride
N,N-DIMETHYL-2-(2-METHYLBENZHYDRYLOXY)-ETHYLAMINE HYDROCHLORIDE
N,N-Dimethyl-2-(alpha-(o-tolyl)benzyloxy)ethylamine hydrochloride
Ethylamine, N,N-dimethyl-2-(phenyl-(o-tolyl)methoxy)-, hydrochloride
Ethylamine, N,N-dimethyl-2-(alpha-(o-tolyl)benzyloxy)-, hydrochloride
n,n-dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylaminehydrochloride
N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylamine hydrochloride
n,n-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-ethylaminhydrochloride
Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride
Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, hydrochloride
EthanaMine,N,N-diMethyl-2-[(2-Methylphenyl)phenylMethoxy]-, hydrochloride (1:1)
o-Methyldiphenhydramine hydrochloride, N,N-Dimethyl-2-(2-methylbenzhydryloxy)ethylamine hydrochloride, β-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride
[EINECS(EC#)]

206-435-4
[Molecular Formula]

C18H24ClNO
[MDL Number]

MFCD00012480
[Molecular Weight]

305.84
[MOL File]

341-69-5.mol
Chemical PropertiesBack Directory
[Appearance]

white crystalline powder
[Melting point ]

159.0 to 164.0 °C
[Boiling point ]

-195 °C
[density ]

0.295 g/cm3
[storage temp. ]

2-8°C
[solubility ]

Freely soluble in water and in ethanol (96 per cent).
[form ]

neat
[color ]

Crystals
[Stability:]

Stable. Incompatible with strong oxidizing agents.
[BRN ]

3745818
[CAS DataBase Reference]

341-69-5(CAS DataBase Reference)
[EPA Substance Registry System]

Orphenadrine hydrochloride (341-69-5)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R22:Harmful if swallowed.
[Safety Statements ]

S36:Wear suitable protective clothing .
[RIDADR ]

3249
[WGK Germany ]

3
[RTECS ]

KR6300000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[Safety Profile]

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl
[Toxicity]

LD50 oral in rat: 255mg/kg
Hazard InformationBack Directory
[General Description]

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.
[Reactivity Profile]

ORPHENADRINE HYDROCHLORIDE(341-69-5) is incompatible with strong oxidizers.
[Air & Water Reactions]

May be sensitive to prolonged exposure to light and air. Water soluble.
[Fire Hazard]

Flash point data for this chemical are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.
[Chemical Properties]

White or almost white, crystalline powder.
[Uses]

Antihistaminic;H1 antogonist
[Definition]

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.
[Biochem/physiol Actions]

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.
[Clinical Use]

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms
[Drug interactions]

Potentially hazardous interactions with other drugs
None known
[Metabolism]

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug
Spectrum DetailBack Directory
[Spectrum Detail]

ORPHENADRINE HYDROCHLORIDE(341-69-5)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

341-69-5(sigmaaldrich)
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